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Author

Domenico Raimondo

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Open access Sep 2026

A selective JNK3-targeting miniprotein confers neuroprotection in a mouse model of ischemic stroke

Ischemic stroke remains a leading cause of death and long-term disability, and current reperfusion therapies do not prevent progressive neuronal loss and neurological decline. Thus, therapeutic strategies targeting intracellular pathways underlying post-ischemic neurodegeneration remain a critical unmet clinical need...

Nunzio Perta, Stefano Fumagalli, C. Villani et al. · 0 citations
Open access Aug 2026

Molecular Striptease of a Thiadiazolopyrimidine Hit Yields a Streamlined, Artifact-Free NADPH Mimic for NOX Inhibition

Compound 5, although aqueous solubility issues limited its cellular antiproliferative performance, represents a specific, artifact-free architectural starting point for future selective NOX inhibitor development.

Emanuele Fabbrizi, Andrea Mancini, Chiara Lambona et al. · 0 citations

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