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Author

Dominic Ferber

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Open access Jul 2026

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Treatment application of Pep19‐2.5 via the nasal aerosol route reduces IL‐1β levels, eosinophil infiltration in bronchoalveolar lavage and significantly improved lung function in an in vivo HDM‐mouse model of allergic airway inflammation.

Jonas Engelhardt, Nico Kirsch, Aileen Kerfin et al. · 0 citations
Open access Aug 2026

AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins

This work presents a scalable mammalian cell-display workflow to identify AI-designed minibinders against cancer surface targets and identifies biochemical optimization beyond the binding interface as a critical requirement for translating AI-minibinders into functional applications.

B. Broske, B. McEnroe, S. C. Frechen et al. · 1 citation

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