Open reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV-associated diseases through autocrine and paracrine mechanisms tha...
Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al.· Frontiers in Pharmacology· 0 citations
Among the newly synthesized scaffolds, the isothiazolo[3,4-b]pyrazines were the most promising, displaying potent and selective PIKfyve inhibition in a biochemical assay, and, in addition, showing antiviral activity against SARS-CoV-2 (in the low μM range).
Ling-Jie Gao, M. Froeyen, Chieh-Wen Lo et al.· Bioorganic chemistry (Print)· 0 citations
Background/Objectives: SARS-CoV-2, the causative agent of COVID-19, relies on its main protease (Mpro) for viral replication, making this enzyme an attractive target for antiviral drug development. In the present study, we investigated whether a library of previously synthesized thiazole/benzothiazole-based thiazolidin...
A. Petrou, Aliki Papadimitriou-Tsantarliotou, Hathaichanok Chuntakaruk et al.· The biochemist· 0 citations
Today's in silico design pipelines can directly yield functional proteinaceous binders without the need for additional experimental screening using phage display or related technologies, and demonstrate that modern in silico design pipelines can directly yield functional proteinaceous binders without the need for addit...
Thibault Vantieghem, Julie Delepine, Sam Noppen et al.· Protein Science· 0 citations
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