Aug 2026
Tumor-derived KLK5 activates TMEM158+ cancer-associated fibroblasts to induce CD8+ T cell exhaustion and confer immunotherapy resistance in lung cancer.
Genetic ablation or functional inhibition of TMEM158⁺ CAFs enhanced sensitivity to anti-PD-1 therapy in LUSC and represent a promising biomarker and therapeutic target.
Shuang-Peng Pu, Guo-Dong Li, Yu-Ran Jiang et al.
· Drug resistance updates · 0 citations