Author

Dong-Jun Lin

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Open access Oct 2026

Increased mitochondrial biogenesis by GPR56 contributes to venetoclax resistance in acute myeloid leukemia

Acute myeloid leukemia is a highly heterogeneous hematologic malignancy with an extremely poor prognosis. Although the BCL-2 inhibitor venetoclax introduced a new therapeutic option for patients, its widespread resistance substantially limited clinical application, and the underlying molecular mechanisms remained inc...

Yu-Sheng Luo, Xin He, Jun-Bin Huang et al. · Cell Death & Disease · 0 citations

Open access Oct 2026

Pharmacological inhibition of PRKDC-mediated DNA damage response by 3-hydroxyflavone selectively alleviates MLL-rearranged acute myeloid leukemia

Rearrangements of the mixed lineage leukemia (MLL) gene in acute myeloid leukemia (AML) have been associated with resistance to chemotherapy, and there is currently an unmet clinical need for effective targeted therapies. In this study, we performed high-throughput drug screening and identified 3-hydroxyflavone (3-...

Jing Liu, Chen-Xing Zhang, Min-Yi Zhao et al. · Cell Death & Disease · 0 citations

Open access Sep 2026

Reduced-intensity post-cyclophosphamide-based graft-versus-host disease prophylaxis for umbilical cord blood transplantation: a single-center pilot study

Background Post-cyclophosphamide (PTCy)-based GVHD prophylaxis has shown significant success in haploidentical transplants. The potential of PTCy in adult umbilical blood transplantation (UCBT) remains unclear due to concerns about engraftment, given the limited number of CD34+ cells. This study aimed to explore the pr...

Yun-Tian Ding, Wei Xiao, Ya-Qun Wang et al. · Frontiers in Immunology · 0 citations