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Dongliang Guan

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Aug 2026

Rational N-Terminal Tuning of Bacitracin A: Repurposing a Classic Antibiotic to Combat Multidrug-Resistant Gram-Positive Pathogens.

A site-selective semisynthetic modification strategy via reductive amination of bacitracin A's N-terminal primary amine is established, providing a rational strategy for bacitracin optimization and highlighting the potential of N-terminal modification for developing improved antibacterial agents.

Si-Jie Cheng, Jing-Wen Liao, Xin-Ru Xia et al. · 0 citations

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