Dong-Liang Huang

Cationic amphiphilic scandenone derivatives as membrane-active anti-MRSA agents.

Methicillin-resistant Staphylococcus aureus (MRSA) remains a major challenge in anti-infective therapy, highlighting the need for antibacterial agents with novel structures and mechanisms of action. Herein, a gram-scale preparation of the natural antibacterial isoflavone scandenone was established, enabling systematic...