Author

Dong-Ling Huang

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Open access Sep 2026

TRPV4-linked oxidative–lysosomal stress in myocardial ischemia/reperfusion: disease-matched transcriptomics and functional analysis in OGD/R cardiomyoblasts

Background Myocardial ischemia/reperfusion (MI/R) injury involves oxidative stress, lysosomal dysfunction, and altered autophagy. TRPV4 may link Ca2+ dysregulation to these processes, but its role in lysosomal membrane permeabilization (LMP) and autophagic impairment remains unclear. Methods Three disease-matched mouse...

Jie Yang, Jin-Cheng Li, Guan-Yao Li et al. · Frontiers in Cell and Develo... · 0 citations

Sep 2026

Metabolomics Profiles and Prognostic Biomarkers in Sepsis Survivors and Nonsurvivors.

INTRODUCTION Sepsis imposes an overwhelming global critical care burden, contributing to an estimated 49 million annual deaths worldwide. Although multiple sepsis-related metabolic profiles have been characterized in prior research, no metabolomic biomarkers have yet entered routine clinical prognostic practice. This s...

Jing Xu, Zhou Huang, He Li et al. · Journal of Surgical Research · 0 citations