Dong-Mei Han

Benchmarking methods for inferring single-cell transcription factor activity using large-scale perturbation sequencing data

A comprehensive evaluation of eight mainstream TFA inference methods using large-scale, high-quality single-cell perturbation sequencing (Perturb-seq) datasets shows that metaTF, which employs an integrated GRN, achieves the best performance across multiple metrics, including TF coverage, predictive accuracy for pertur...