Author

Dong-Ming Zhou

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Open access Aug 2026

An adenovirus-based multiantigen vaccine protects against tuberculosis by coordinating adaptive immunity and curbing immunosuppressive mechanisms

The identification of a multi-antigen vaccine candidate, Ad-8CPR2, as the most immunogenic construct, which incorporates M. tuberculosis antigenic proteins with strong immunogenicity and functional properties, which are fused with peptide segments capable of augmenting antigen-specific immune responses.

Li-Qun Wei, Peng Wang, Ying Li et al. · Microbiology spectrum · 0 citations

Open access Jul 2026

Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice

A chimpanzee adenovirus (AdC68)-vectored vaccine expressing the Delta-XBB receptor-binding domain (RBD)-dimer is constructed and comprehensively compared the immune responses induced by intramuscular injection, intranasal administration, or aerosol inhalation, revealing that aerosol inhalation provided significantly be...

Xue-Yuan Liu, Yaling An, Huixin Duan et al. · mBio · 0 citations