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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Dongwei Kang

h-index 35 View on Semantic Scholar

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Oct 2026

Discovery of C5-Substituted 2′-Fluorinated Pyrimidine Nucleosides as Potent and Orally Efficacious Anti-HSV Agents

Herpes simplex virus (HSV) infections remain a significant global health concern. Through phenotypic screening of a nucleoside-focused library followed by systematic structure−activity relationship (SAR) explorations, we identified C5-substituted 2′-fluorinated pyrimidine nucleosides as promising anti-HSV scaffolds....

Ye Li, Wen-Bo Zhang, Shu-Wen Xue et al. · 0 citations
Aug 2026

Discovery of pyridine formyl hydrazide derivatives as potent non-nucleoside RSV polymerase inhibitors.

Respiratory syncytial virus (RSV) is an RNA virus that infects both the upper and lower respiratory tract and is recognized as a major respiratory health threat. In this study, guided by the cryo-EM structure of the MRK-1-RSV polymerase complex, the substituent region at the C4 position of the shared pyridine core was...

Xin Li, Jinyuan Wu, Lin Zheng et al. · 0 citations
Review Jul 2026

Research Progress and Challenges of Anti-monkeypox Virus Drugs Targeting F13 Protein.

Future paradigms must break away from standalone F13 monotherapy and transition toward combination regimens, such as pairing F13 blockers with host-targeting entry/uncoating inhibitors─or developing multitarget inhibitors that interrupt the viral life cycle prior to IMV maturation by targeting DNA polymerase or transcr...

Le Wang, Tao Zhang, Jie Guo et al. · 1 citation

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