Rheumatoid arthritis (RA) is a persistent autoimmune condition that predominantly affects the joints resulting in inflammation, pain and progressive disability. Immunological imbalance, especially the stimulation of pathogenic immune cells, including T and B cells, macrophages, amongst others, is the cause of the disea...
Yan-Hai Dong, Xi-Fang Xu, S. S. et al.· Frontiers in Immunology· 0 citations
This work developed a 5' triphosphorylated oligonucleotide (imm-miR223) with dual function as miR-223 analogue and RIG-I activation, and delivered this RNA molecule to HCC cells efficiently using normal hepatic cell-derived extracellular vesicles (EVs).