Carboxymethyl chitosan-sodium alginate/carboxymethyl cellulose pH-responsive efficient drug-loaded gel for the treatment of inflammatory bowel disease.
Budesonide offers potent anti-inflammatory activity and high first-pass metabolism for oral IBD therapy, but existing dosage forms suffer from gastric leakage and intestinal burst release. pH-responsive hydrogel faces a fundamental trade-off: high crosslinking ensures encapsulation yet suppresses release, whereas low c...