Author

D. Jiang

2 papers indexed here

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Open access Oct 2026

Targeting PRPF19 suppresses lung cancer progression by abrogating cytokinesis and potentiating anti-tumor immunity

Lung cancer remains the leading cause of cancer-related mortality worldwide, highlighting the critical need to identify key oncogenic drivers and develop effective therapeutic strategies. Here, we demonstrate that pre-mRNA processing factor 19 (PRPF19) is significantly upregulated in lung cancer tissues and correla...

Shuai-Hu Li, Long-Fu Zhang, Tian Xu et al. · Cell Death & Disease · 0 citations

Aug 2026

Targeting GEM Reprograms Macrophages and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma.

GTP-binding protein overexpressed in skeletal muscle (GEM) is identified as a tumor cell-intrinsic regulator associated with poor response to anti-PD-L1 therapy in ESCC and a GEM-SERPINE1-LRP1 signaling axis that drives macrophage-mediated immune suppression is defined.

Lin-Feng Wu, C. Ren, Yi-Fei Zhang et al. · Cancer Research · 0 citations