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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Dongxuan Ni

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Oct 2026

Discovery of Diaryl Pyrimidine-Guanidine Derivatives as Jumonji C Domain-Containing Lysine Histone Demethylase (KDM) Inhibitors with In Vivo Anti-Cervical Cancer Activity

JMJD family histone demethylases are highly expressed in cervical cancer and promote tumor progression, highlighting their potential as therapeutic targets for this malignancy. Using a scaffold-hopping-based virtual screening, we discovered a series of diaryl pyrimidine-guanidine derivatives as KDM6B inhibitors. The...

Dong-Xuan Ni, Ting Wang, Ji-Jian Yang et al. · 0 citations
Open access Jul 2026

Design and synthesis of quinazoline derivatives as novel JMJD3/HDAC dual-target inhibitors.

A series of novel quinazoline derivatives designed and synthesized as potent dual inhibitors targeting histone lysine demethylase JMJD3 and histone deacetylases provide a novel scaffold for dual-target epigenetic drug discovery, a valuable chemical probe for investigating epigenetic crosstalk, and a promising candidate...

Li-Wei Wang, Yuke Zhang, Ke-Tong Chen et al. · 0 citations

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