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Review Open access Sep 2026

LAPTM4B in tumor immune evasion: lysosomal autophagy, metabolic adaptation, and therapeutic resistance

Tumor immune evasion is shaped not only by canonical immune checkpoints but also by lysosomal stress adaptation, autophagy, metabolic remodeling, and therapy-induced survival programs within malignant cells. Lysosomal-associated protein transmembrane 4 beta (LAPTM4B), an oncogenic lysosomal transmembrane protein, h...

Hao-Kun Leng, Ze-Tong Zheng, Rui-Zheng Li et al. · 0 citations
Aug 2026

UNCX/SIN3A-Mediated H4K8 decrotonylation suppresses FOXO3 to drive TNBC progression and docetaxel resistance.

Triple-negative breast cancer (TNBC) remains a clinically challenging subtype characterized by aggressive behavior and limited treatment options. Though docetaxel remains a cornerstone chemotherapy for TNBC, the frequent emergence of resistance highlights the urgent need to identify novel therapeutic targets. In this s...

Song-Fu Shi, Dong Yan, Lixin Zhao et al. · 0 citations

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