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Author

Dongfang Tang

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Open access Sep 2026

Improving the Accuracy of Papillary Thyroid Cancer Pathological Evaluation With Digital PCR Detection of the BRAF V600E Mutation

ABSTRACT Background The BRAF V600E mutation is an important diagnostic factor for papillary thyroid cancer (PTC). Digital PCR (dPCR) is a relatively new technology featured with extremely high sensitivity. This study aims to evaluate the performance of dPCR in detecting BRAF V600E mutations in PTC diagnosis. Methods A...

Na Yu, Kai Zhang, Ying Jiang et al. · 0 citations
Open access Aug 2026

ST6GAL1 promotes cancer stem-like cell-associated paclitaxel resistance through the EGFR-mTOR-SOX2/BMI1 axis in non-small cell lung cancer

ST6GAL1-mediated α2,6-sialylation of EGFR contributes to the maintenance of CSLC-associated paclitaxel resistance through mTOR-SOX2/BMI1 signaling, which identifies ST6GAL1-dependent EGFR sialylation as a potential therapeutic target in CSLC-associated chemoresistance.

Yu-Xi Yang, Bing-Hui Liang, W. Hong et al. · 1 citation
Open access Jul 2026

A three-gene signature correlated with MAPK/ERK activation characterizes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer

It is suggested that MAPK/ERK signaling contributes to the transition from adaptive tolerance to stable resistance to afatinib and highlight a tractable therapeutic vulnerability for overcoming resistance to tyrosine kinase inhibitors in NSCLC.

Chang-Tai Qin, Wei Zhang, Dongfang Tang et al. · 0 citations

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