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Author

Doreen Meier

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Open access Sep 2026

DUF4004 protein BacR (YhbD) of Bacillus subtilis is a regulator of bactofilin expression and interacts with bactofilins in a switch-like manner

Introduction DUF4004-containing proteins are found in a variety of bacteria. The only characterized member was shown to act as transcriptional repressor of genes involved in metabolism in Clostridium acetobutylicum. We have characterized the B. subtilis member of this protein family, encoded by the yhbD gene. The absen...

Kristin Velten, Patrik Brück, Shahla Alipour et al. · 0 citations
Open access Sep 2026

Dynamic expression range expansion of ECF sigma factor-dependent synthetic regulons by promoter context engineering

The results establish promoter environment engineering as a robust strategy for expanding the dynamic range of orthogonal ECF regulatory systems and facilitate the scalable design of synthetic transcriptional programs in bacteria.

C. Rauch, Doreen Meier, Vinca N. Seiler et al. · 0 citations

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