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Dorien Pastoors

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Oct 2026

Cohesin Mutations in Cancer and Development

Cohesin is a ring-shaped protein complex that wraps around DNA and is crucial for sister chromatid cohesion, chromatin organization, gene regulation, replication, and DNA damage repair. In somatic cells, it consists of the core ring subunits SMC1A, SMC3, and RAD21 and one of two paralogs, STAG1 or STAG2. Germline mutat...

Dorien Pastoors, Emilie de Vet, Zuzana Tothova · 0 citations

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