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Author

Dorota Latek

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2 papers indexed here

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Sep 2026

C5aR2 signaling mechanisms via the β-arrestin-dependent pathway observed in microsecond-scale molecular dynamics simulations.

This extensive 4-μs-long, 6-replica molecular dynamics study provides important insights into the molecular basis of C5aR2 signaling, which can lead to either proinflammatory or anti-inflammatory effects, and could be exploited in the treatment of inflammatory diseases.

Paulina Dragan, Dorota Latek · 1 citation
Open access Sep 2026

Microswitch-Guided Sampling for the Detection of Ligand Signaling Bias in GPCR Systems

Biased signaling occurs when a ligand preferentially activates a specific signaling pathway at a certain receptor within a particular cellular environment. As pharmaceuticals, functionally selective (biased) compounds can engage beneficial signaling pathways while avoiding those linked to adverse effects, resulting in...

Paulina Dragan, Dorota Latek · 0 citations

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