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Author

Dorothy Duan

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Jul 2026

Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids.

The rational design, synthesis, and mechanistic investigation of cyclopentene-based γ-aminobutyric acid analogues bearing alkyne or nitrile warheads as potent hOAT inactivators are reported, expanding the mechanistic repertoire of PLP-dependent enzyme inactivation and providing a generalizable framework for designing highly selective mechanism-based inactivators.

Feng Wang, M. Corrigan, N. Le et al. · 0 citations