Author

Dorothy P. Schafer

2 papers indexed here

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Open access Aug 2026

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis

Group A Streptococcus (GAS) infections cause neuropsychiatric complications in children, but the mechanisms linking peripheral infection to brain dysfunction remain unclear. Using mouse genetics, single-cell RNA sequencing, and spatial transcriptomics, we show that GAS infections induce inflammatory transcriptional pro...

C. R. Wayne, U. Akcan, Travis E. Faust et al. · Nature Communications · 0 citations

Review Jul 2026

Glia orchestrate neural circuit development.

Over the past ∼25 years, our understanding of neural circuit development in the central nervous system has shifted. Once considered passive supporters, glial cells, namely, astrocytes, oligodendrocyte lineage cells, and microglia, are increasingly recognized as active regulators of developmental circuit formation and m...

K. Sakers, Patrick W. Sheehan, Wendy Xin et al. · Developmental Cell · 0 citations