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Author

Douglas D. Fraser

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Review Open access Sep 2026

Heterogeneity of Treatment Effect by Molecular Endotype in Acute Respiratory Distress Syndrome: A Systematic Review.

A systematic review to evaluate effect modification by molecular endotype across randomized ARDS trials and assess credibility of reported subgroup effects exposed current knowledge gaps in how subgroups are defined and inform future clinical practice guideline recommendations.

L. V. Van Nynatten, Chris McChesney, Mujtaba M. Basharat et al. · 0 citations
Review Open access Jul 2026

The molecular ICU: a primer on omics, informatics and the future of precision critical care

This Review proposes pathway-focused biomarkers as clinically translatable signatures that preserve biological mechanisms while enabling practical measurement, and outlines how pathway enrichment, network analysis, and multi-omic integration can identify these programs, and how feature selection can derive parsimonious...

L. V. Van Nynatten, Hira Raheel, J. Basmaji et al. · 2 citations

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