Dr. Raji M K*, Aliya Sheraf, Anjana G, Devapriya B, Henna Reji, Nirbhaja P K

SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS (SNEDDS): FORMULATION PRINCIPLES, MECHANISTIC INSIGHTS, AND BIOPHARMACEUTIC PERSPECTIVES FOR ENHANCED ORAL BIOAVAILABILITY

Poor aqueous solubility affects roughly 40% of newly discovered drug candidates, most of them BCS Class II, and remains a principal limitation on oral bioavailability. Self-nanoemulsifying drug delivery systems (SNEDDS) — isotropic, anhydrous pre-concentrates of oil, surfactant, and co-solvent that spontaneously form n...