Dr Shahid Ahmad Shergojry

TUMOR MICROENVIRONMENT DYNAMICS: MOLECULAR AND GENETIC DETERMINANTS OF CANCER PROGRESSION AND THERAPY RESPONSE

The evidence demonstrates that growth factor signalling, inflammatory pathways, hypoxia, metabolic reprogramming, genetic and epigenetic alterations, and extracellular vesicle-mediated communication alter the tumour microenvironment, encouraging tumour growth, metastasis, immune escape, and resistance to immunotherapy, chemotherapy, radiation, and targeted treatment.