Dr. Vinod Ugale

Neuroprotective Potential of Phytochemicals: Exploration of Molecular Mechanisms in Neurodegeneration.

Neurodegeneration is a progressive loss of neuronal structure and function. Oxidative stress, neuroinflammation, mitochondrial dysfunction, excitotoxicity, and abnormal protein misfolding disrupt neural homeostasis leading to neurodegeneration. Phytochemicals have been used in the treatment of several diseases in the p...

UPS-mediated P-glycoprotein regulation in Alzheimer’s disease: pharmacological implications for the amyloid pathology

Ferroptosis and NMDA Receptor Activity in Alzheimer's Disease: Implications for Amyloid Pathology and P‐Glycoprotein Regulation

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline, amyloid‐β (Aβ) accumulation, oxidative stress, and excitotoxicity. Ferroptosis and N‐methyl‐D‐aspartate (NMDA) receptor activity,may be interconnected in the pathogenesis of Aβ accumulation and associ...