Author

Drashti Shah

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Review Sep 2026

Quinazoline-based VEGFR-2 Inhibitors: A Comprehensive Review of Design Strategies, SAR, and Therapeutic Advances.

INTRODUCTION Angiogenesis, primarily controlled by Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2), significantly influences tumor growth and metastasis. Consequently, VEGFR-2 targeting has emerged as an important strategy for cancer treatment. Owing to their known efficacy as strong tyrosine kinase inhibitors,...

A. Yadav, Drashti Shah, Princy Desai et al. · Current Drug Targets · 0 citations

Aug 2026

Mechanochemical Synthesis, Characterization, and Biological Evaluation of N-Cyclohexyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxamide Derivatives

These findings demonstrate that mechanochemically synthesized THPM scaffolds represent highly promising lead structures for sustainable anti-TB drug discovery.

Drashti Shah, Ashish Patel · Russian journal of bioorgani... · 0 citations

Review Jul 2026

Recent advances in 1,3,5-triazine-based PI3K inhibitors for cancer therapy: a comprehensive review.

This comprehensive review critically summarizes advances from 2021-2025 in the design of selective PI3K inhibitors based on the 1,3,5-triazine (s-triazine) scaffold, emphasizing how its symmetric 2/4/6 substitution vectors, electron-deficient hinge-binding profile, and modular cyanuric chloride - enabled SNAr synthesis...

Utkarsha Kulkarni, Adarsh Yadav, Princy Desai et al. · Future Medicinal Chemistry · 0 citations