Ritonavir-Loaded PEG-b-PCL Polymeric Micelles: Reduced Excipient Requirements and Comparable Oral Pharmacokinetics in Rats
Background: Ritonavir (RTV), an HIV-1 (human immunodeficiency virus-1) protease inhibitor, has low aqueous solubility and poor oral bioavailability, requiring large amounts of excipients that result in bulky dosage forms and poor patient compliance. We aimed to develop an RTV-loaded polymeric micelle formulation with h...