Dun-Ya Yang

The deubiquitinating enzyme regulatory network in malignant progression of breast cancer encompasses mechanisms of action, clinical significance and emerging therapeutic targets

Breast cancer progression is orchestrated by a networked regulatory architecture of deubiquitinases (DUBs), defined by functional convergence, pathway pleiotropy, and complementary parallel layers. This review elucidates how this integrated circuitry governs breast cancer malignancy, therapy resistance, and immun...