SIRT1 activator resveratrol improves the ALF-induced cognitive and motor function deficits in rats via modulating glutamate-NMDAR-NOS-cGMP pathway.
Acute liver failure (ALF) is a life-threatening condition often leading to hepatic encephalopathy (HE), a neuropsychiatric disorder characterized by cognitive deficits and motor dysfunction due to elevated ammonia levels and neuroinflammation. This study investigates the therapeutic potential of resveratrol (RSV), a SI...