Interplay between flap endonuclease 1 and DNA polymerase β in long patch base excision repair: new facets in mechanism
Mammalian base excision repair (BER) is the major repair pathway for correcting small DNA base lesions. BER operates via two sub-pathways: short patch (or single nucleotide) and long patch BER (SP-BER and LP-BER, respectively). In LP-BER, DNA polymerase beta (Polβ) performs strand-displacement synthesis generating a 5’...