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Aug 2026

New Tetrazole-1,3,4-Oxadiazole and 1,2,4-Triazole-based Benzothiazole Hybrids: Synthesis, Anticancer Activity, and Computational Investigations

Abstract Cancer is the most complex disease and safety of current drugs represents serious challenge to develop safer medications. Novel hybrids of sugar–benzothiazole–tetrazole–hydrazones, their derived 1,3,4-oxadiazoles and the 1,2,4-triazole glycoside were synthesized to study their anticancer potential with mechani...

Asmaa F. Kassem, Lama A. Alshabani, Asmaa Saleh et al. · 0 citations
Sep 2026

Bis-thiosemicarbazone derivative as starting agent for synthesis of anti-breast cancer agents and targeting PIM-1 kinase.

AIMS To design, synthesize, and biologically evaluate novel bis-thiazole derivatives as potential PIM-1 kinase inhibitors for breast cancer therapy. MATERIALS AND METHODS A series of new bis-thiazole derivatives were synthesized and evaluated for their antiproliferative activity against MDA-MB-231 and MCF-7 breast ca...

Alaa M. Abu Alnjaa, Jihan Qurban, E. Abbas et al. · 0 citations

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