Open access
Aug 2026
ATP13A4 gates extracellular polyamine levels to control excitatory synaptogenesis
Polyamines, such as spermidine, are essential regulators of brain development, yet how cells control their uptake and extracellular levels remains unclear. Here we show that ATP13A4, a transport protein enriched in glia and prominently expressed in astrocytes, governs brain polyamine balance. Using biochemical, cellula...
S. van Veen, Emily Meeus, D. Irala et al.
· Nature Communications · 1 citation