Author

E. Bağırsakçı

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Review Open access Aug 2026

Epigenetic reprogramming of lineage switching in cancer.

This review evaluating how the antagonistic interplay between Polycomb and Trithorax complexes, chromatin modifier activity, and enhancer reprogramming affects lineage identity and enables multi-lineage plasticity in cancer underscores epigenetic deregulation as a primary driver of lineage plasticity and intratumoral heterogeneity.

Ezgi Boyvatlı, Burcu Akman, E. Bağırsakçı et al. · FEBS Letters · 0 citations