Jul 2026
Mechanistic insights into EB171 anticancer activity in MCF7 and MDA-MB-231 breast cancer cells showing differential responses.
Mechanistically, EB171 induced replication stress and DNA double-strand breaks, accompanied by activation of cell cycle checkpoints, cyclin suppression, and p21Waf1/Cip1 upregulation, and these findings support further investigation of EB171 as a promising anticancer compound.
Zuzanna Rzepka, Dominika Stencel, E. Bębenek et al.
· Toxicology and Applied Pharm... · 0 citations