Author

E. Beck

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Open access Sep 2026

The Potential Public Health Benefit of mRNA-1010 for Influenza Among Older Adults >=65 Years in the United States

Background/ObjectivesOlder adults are at high risk of influenza-related severe disease and complications. HD-IIV, currently recommended for adults [≥]65 years, is egg-based and may be subject to egg-adapted mutations. An mRNA-based vaccine for influenza, mRNA-1010, has been approved by the Food and Drug Administration....

K. Fust, E. Beck, M. Kohli et al. · medRxiv · 0 citations

Open access Aug 2026

Estimating the Relative Vaccine Efficacy of mRNA-1010 to High-Dose Influenza Vaccine in Adults ≥65 Years Using a Correlate of Protection Framework

Background/objective: Older adults experience a disproportionate burden of severe influenza. In the P303 trial (NCT058279789), mRNA-1010 showed greater immunogenicity versus high-dose inactivated influenza vaccine (HD-IIV4) in adults ≥65 years of age. Here, we used a correlate-of-protection framework to estimate the re...

V. Nguyen, Ethan Settembre, John Youhanna et al. · Vaccines · 0 citations