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Sep 2026

From Photoswitch to Polycycle: Structure-Reactivity Relationships in the Photoinduced Isomerization-Cyclization of Amino(hetero)arylidene-thiazolidine-2,4-diones.

We report a comprehensive study of the photoinduced isomerization-cyclization cascade of o-amino(hetero)arylidenethiazolidine-2,4-diones (Het)Ar-TZDs 1, combining computational, synthetic, and kinetic investigations. Time-dependent density functional theory (TD-DFT) calculations were used to predict absorption maxima a...

Vincent Bruneau, Johanne Coutard, Nina Bukhtiiarova et al. · 0 citations
Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · 1 citation

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