Association Between Age-Dependent DNA Methylation Changes at FKBP5 Enhancer Sites and Increased Cortical Gene Expression in Schizophrenia.
OBJECTIVE An increasingly compelling body of literature indicates that the glucocorticoid receptor cochaperone FK506-binding protein 51 (FKBP51; encoded by FKBP5) is a promising target for psychiatric therapeutics. Increased mRNA expression of FKBP5 in postmortem brains with psychiatric diagnoses and with aging have be...