Open access
Sep 2026
Aβ-induced CaMKII hyperactivation is associated with impaired lysosomal maturation and mitophagy.
Findings indicate that CaMKII hyperactivation contributes to Aβ25-35-induced autophagy-lysosomal dysfunction and neuronal damage, and that pharmacological inhibition of CaMKII with KN93 restores intracellular degradative capacity and ameliorates cognitive impairment under Aβ stress.
E. C. Suh, Yul A. Kim, K. Lee et al.
· Neurochemistry International · 0 citations