Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that depends on its ability to spread from host to host to survive as a species. Knowledge of traits supporting transmission is lacking. Here, because desiccation occurs during the generation of Mtb-transmitting aerosol droplets, we exposed Mtb mounted atop...
C. Brown, Brendon M. Lee, H. M. Liu et al.· Nature Microbiology· 1 citation
Compact viral genomes encode sophisticated strategies to reprogram host gene expression, often by co-opting rather than replacing RNA polymerase. How bacteriophages achieve such control in Mycobacteria remains largely unknown. Here, time-resolved interaction proteomics of mycobacteriophage D29 infection identifies a co...
David R. Parker, Shrestha Ghosh, Adela Dujiskova et al.· bioRxiv· 0 citations
Bacteria and archaea often harbor multiple CRISPR-Cas loci to defend against mobile genetic elements. Little is known, however, about whether and how different CRISPR-Cas systems are differentially regulated, in many instances due to the impossibility of studying CRISPR immunity in native hosts. Here we investigated th...
M. Brodmann, Christian F. Baca, Joshua Chandanani et al.· Nature Communications· 0 citations
Combined pooled-AlphaFold3 PPI prediction and high-throughput genomics approach is established as the gold standard for large-scale characterization of protein function.
Horia Todor, Lili M. Kim, Evan Billings et al.· bioRxiv· 0 citations
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