Author

E. D. de Freitas

2 papers indexed here

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Review Open access Aug 2026

Mechanistic Drivers of Thermogenic Adipose Tissue Dysfunction in Aging and Obesity.

Population aging is accelerating worldwide, and is accompanied by a growing burden of chronic metabolic diseases. Adipose tissue dysfunction represents a central mechanism linking aging and obesity to metabolic decline, contributing to chronic low-grade inflammation, impaired adipokine signaling, ectopic lipid depositi...

Gabriela Ueta Ortiz, G. Abud, Caroline Fogagnolo et al. · American Journal of Physiolo... · 1 citation

Review Open access Sep 2026

Integrated Multi-Omics Network by Physical Exercise Across Aging: Molecular Adaptation Beyond Single Signaling Pathways.

Aging is characterized by progressive molecular dysregulation across interconnected biological systems, involving alterations in epigenetic regulation, gene expression, protein homeostasis, and metabolic function. Although physical exercise is widely recognized as one of the most effective non-pharmacological intervent...

Guilherme da Silva Rodrigues, I. V. de Sousa, Takuji Kawamura et al. · Physiological Genomics · 0 citations