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Review Open access Aug 2026

Preserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization

Knee osteoarthritis (KOA) is a leading cause of late-life pain, mobility loss, and disability, and is increasingly recognized as a phenotype-dependent manifestation of joint aging rather than a purely mechanical disorder. Cellular senescence, inflammaging, mitochondrial dysfunction, synovial inflammation, vascular remo...

Á. Bérczi, F. Szablics, Dóra Hámori et al. · 0 citations
Review Open access Aug 2026

Zilebesiran, a Small Interfering RNA Therapeutic Targeting Angiotensinogen: Mechanism, Clinical Evidence, Safety, and Implementation Considerations

Zilebesiran is a first-in-class, subcutaneously administered small interfering RNA therapeutic that selectively silences angiotensinogen messenger RNA, the transcript encoding the common precursor of all angiotensin peptides and produces durable blood pressure lowering that can persist for up to 6 months after a single...

Jawaria, A. Noor, Yusra Zarlashat et al. · 0 citations

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