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Author

E. García-Torralba

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Jul 2026

A transcriptional signature of resting mast cells is associated with improved disease outcome in HR+HER2- breast cancer.

Analysis of transcriptional signatures of immune cell infiltration across three public transcriptomic datasets from patients with breast cancer suggests interactions between mast cells and non-malignant components of the breast cancer microenvironment, particularly fibroblasts, may shape disease progression and treatme...

A. Kirchmair, C. Galassi, E. García-Torralba et al. · 0 citations
Open access Jul 2026

Impact of BRCA2 pathogenic variants on outcomes to first-line CDK4/6 inhibitors plus endocrine therapy in HR-positive/HER2-negative metastatic breast cancer

BRCA2 PVs were independently associated with poorer outcomes to first-line CDK4/6i plus ET in HR-positive/HER2-negative MBC compared with controls, especially relevant among patients with endocrine-sensitive disease.

M. Cruellas, A. Rodriguez-Hernandez, L. Carità et al. · 0 citations

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