Author

E. Giamarellos-Bourboulis

2 papers indexed here

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Review Open access Sep 2026

The NLRP3 inflammasome in physiological and dysfunctional host response in human sepsis and critical illness: a narrative review

The NLRP3 inflammasome is a cytosolic multiprotein complex that serves as a key regulator of innate immunity by reacting to pathogen- and damage-associated signals and orchestrating downstream inflammatory responses. Inflammasome activation induces caspase-1-dependent maturation of interleukin (IL)-1β, IL-18 and gasder...

Caroline Neumann, Florian Hickl, Julia Kemnitzer et al. · Critical Care · 0 citations

Open access Jul 2026

A human-specific long noncoding RNA regulator of antigen-presenting cell viability and antimicrobial defense.

Macrophages are essential for both, to clear pathogens and preserve tissue homeostasis, yet the molecular regulators of this equilibrium remain incompletely defined. Here, we identify SAILR (survival associated immune-regulatory RNA), a primate-specific long noncoding RNA (lncRNA), as a critical modulator of macrophage...

A. Westermann, Alexandra Schock, Diyaa Al Din Ashour et al. · Proceedings of the National... · 0 citations