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Author

E. Giang

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Open access Aug 2026

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mapping

This study illustrates how alternative antibody repertoires can reveal functionally important antigenic surfaces that are underrepresented in conventional human antibody responses, providing new opportunities for the rational design of next-generation HCV vaccine immunogens.

Haneen Tarabih, Jenna Weisz, Itai Yechezkel et al. · 0 citations
Open access Aug 2026

The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages.

Describing the genetic, structural, functional, and epitope features of 25 BD-directed nAbs isolated from HCV-infected individuals or immunized macaques underscores BD as a promising target for rational HCV vaccine design.

Fang Chen, Yen Thi Kim Nguyen, Yi-Zong Lee et al. · 0 citations

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