SGLT2i attenuates biventricular remodeling and preserves connexin 43 in experimental volume-overload heart failure
Heart failure (HF) caused by chronic volume overload is associated with progressive structural, electrical, and metabolic remodeling, leading to ventricular dysfunction and increased arrhythmogenic risk. Although sodium–glucose cotransporter-2 inhibitors (SGLT2i) provide significant cardioprotection, their glucose-in...