Open access
Jul 2026
Complex intra-host SARS-CoV-2 evolution following monoclonal antibody pre-exposure prophylaxis
Sotrovimab pre-exposure prophylaxis in an immunocompromised patient did not prevent SARS-CoV-2 infection, and was selected for resistant mutation E340D, with unexpected fitness consequences across non-receptor binding domain spike regions.
K. Kamelian, D. Pascall, Mei-Jun Cheng et al.
· medRxiv · 1 citation