Open access
Aug 2026
Mendelian randomisation and colocalisation reveal pleiotropic effects of the CD40/SLC12A5 locus on CD40 protein, depression, and immune disease
Results emphasise the value of combining Mendelian randomisation with colocalisation to separate shared biology from correlated signals in genomic regions where multiple traits map to the same locus (pleiotropy).
R. Laattoe, E. Hyppönen, D. Stacey et al.
· Translational Psychiatry · 0 citations