ARL4C in oral cancer cells promotes stromal RANKL expression via a RelA-dependent inflammatory axis in stromal fibroblasts
Jawbone destruction in oral squamous cell carcinoma (OSCC) is driven by receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-mediated osteoclastogenesis. Although the cellular sources of RANKL and its regulatory mechanisms within the OSCC microenvironment remain elusive, this study aimed to elucidate ho...