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Author

E. Joffré

3 papers indexed here

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Open access Sep 2026

Post-infection colonization and recurrent infections by ST11-KL64 carbapenem-resistant Klebsiella pneumoniae: a study of within-host evolution

ABSTRACT Bacteria pose a serious threat to hosts through adaptive mutations that confer stress resistance and promote persistent colonization. Here, we describe an adaptive evolution event involving eight highly similar ST11-KL64 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, isolated from a non-infected in...

Jiao Xu, Ya-Xu Leng, Qiao-Ling Chen et al. · 0 citations
Open access Aug 2026

Novel phage-plasmid mediated mechanism of antibiotic heteroresistance in Escherichia coli

A novel mechanism of HR by gene copy number increase is identified and further elucidates the role of phage-plasmids in antibiotic resistance development and spread and shows that a piperacillin-tazobactam-selected increase in phage-plasmid copy number did not increase the rate of horizontal transfer of the phage-plasm...

Elin Svedholm, E. Joffré, Caroline Sentell et al. · 0 citations
Aug 2026

Distinct plasmid- and host-encoded mechanisms drive small plasmid copy number-mediated heteroresistance in Escherichia coli

This study investigates the contribution of small plasmids to heteroresistance using a clinical bloodstream Escherichia coli isolate carrying a 12 kb ColE1-type plasmid, and shows that this plasmid drives transient β-lactam heteroresistance through massive increases in plasmid copy number.

Angelika Ntokaki, E. Joffré, Bart Melgers et al. · 0 citations

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